Achievements
MAJOR ACHIEVEMENTS
RESEARCH AND DEVELOPMENT
- Transgenic cotton plants containing double gene GUSP1 and HSP70 and LTP are developed which are tolerant against heat and drought
- Approvals for CKC-5 (triple-gene) from Punjab Seed council and CKK (five-gene) insect-resistant and weedicide-tolerant cotton variety for field trial permission from NBC
- Salt-tolerant and drought-resistant cotton varieties have been successfully developed and subjected to field- testing
- Developed pest resistant potato through genome editing and subjected to field evaluation
- Developed True Potato Seed through breeding longer shelf-life potato and pest resistant
- Discovered novel bacteriophages indigenously, that offer significant potential to combat critical health challenges such as infections caused by Multi Drug Resistant (MDR) Bacteria
- miRNA-based Drug-Resistant genes silencing in cancer cell lines, were performed at molecular level
- Conducted initial field trials of the larvicidal transgenic algae on the floating treatment wetlands (FTWs)
- Assessed the immunogenicity of the Chlamydomonas reinhardtii expressed influenza CTB-M2e fusion protein in mice
- Identified the potential therapeutic agents against Epilepsy and Parkinson’s disease and reported the four medicinal plants with potential anticancer activity
- Genetic variations of 30 InDels markers in Azad Jammu and Kashmir Population were identified
- Downstream process development/optimization for the process development of Filgrastim (B
- FMDV polyepitope vaccine protein was expressed in E. coli, leading to successful antibody production
- The compound Reserpine has been identified as a strong liver anti-fibrotic agent. The compound Reserpine ameliorated liver fibrosis by targeting the Keap1/Nrf2 pathway
- The potential significance of targeting MALAT1 as a therapeutic strategy for breast cancer was identified
- The compounds Betanin and Glycine Betaine downregulated expression of dengue-2 NS3 expression.
- Coffea arabica extract was shown to have anti-inflammatory and antiarthritic effect in vitro and in vivo
- Demonstrated that Cassia Angustifolia-primed ASCs and Plantago lanceolata and Tussilago farfara-mediated human adipose-derived stem cell therapy effectively enhance burn wound healing
- Exosome investigation for tendon injury repair is in process
- Developed stem cell derived exosome therapy for of liver fibrosis in rat models
- Developed chitosan-sodium percarbonate-based hydrogels with sustained oxygen release, angiogenic and wound healing properties
- Identification of potent senolytic drugs capable of eliminating senescent cells in in vitro diabetic cellular model
- Clinical trials investigating the efficacy of ASCs supplemented with platelet rich plasma for diabetic foot ulcer patients in collaboration with JBRSC, Lahore, are ongoing with promising therapeutic outcomes
- Clinical trials for Osteoarthritis and spinal cord injury patients are ongoing
- Novel Variants identified in NAV3 gene, a neuronal morphogenesis protein, cause intellectual disability, developmental delay, and microcephaly
COMMERCIALIZATION/ INDUSTRY
- Set up commercial facilities for DNA testing, Qubit quantification and cost-effective BRCA1/2 screening for cancers
- A three-gene cotton variety CEMB-AAS3 was recommended by the Varietal Evaluation Committee, PCCC
- Conducted pharmacokinetics and drug toxicity studies of Semaglutide for the biopharmaceutical industry, valued at PKR 1.6 million
- Produced PCR Enzymes and kits for in-house use, worth PKR 4.6 million
- Revived Molecular diagnostics laboratory for hepatitis testing
GRANTS / FUNDINGS
- Four TDF projects: PKR 46 million; twenty-six PU Projects: PKR 5.8 million; a CPEC project: PKR 12.963 million; 1 WHO project (AP24-01787): PKR 2.5 million
- Ongoing: European Foundation: €125,000; Islamic Development Bank: 38.36 million PKR; Turkiye industrial: USD 25,000
PATENTS/MOUs/AGREEMENTS AND COLLABORATIONS
- 01 Patent awarded 04 submitted, Signed 10 MOUs, Agreements and several collaborations with different institutions at National & International levels
ACADEMIA
- Produced 48 M.Phil and 12 Ph.Ds. Published 89 Research Articles (impact factor of 261.614), 10 Book Chapters.
- CEMB organized 28 conferences/scientific events, faculty and students actively participated in national and international conferences, symposia, seminars and training workshops.
- CEMB provided internships to 53 students from institutions all over Pakistan.