Muhammad Islam Khan specializes in the intersection of protein engineering and downstream processing. He has played a significant role in the development of therapeutic proteins with substantial clinical impact, including interferon, insulin, G-CSF, IL-1Ra antagonist, interlukin29, IGF-1, and EGF. His work covers the entire spectrum, from the initial stages of design and optimization to the intricate processes of purifying and expressing recombinant proteins in yeast, bacteria, and green algae.

One of his noteworthy achievements is the refinement of the anti-EGFR antibody scFv, a pivotal element in targeted cancer therapies. His efforts in this field have contributed to unlocking the potential of this antibody fragment, paving the way for more effective and personalized approaches in the battle against cancer.

Beyond the laboratory, he has delved into anticancer studies, exploring the therapeutic potential of proteins. Through meticulous experimentation and rigorous analysis, he has aimed to uncover the mechanisms by which these proteins can combat cancer cells and potentially reshape the landscape of oncology treatment.

Furthermore, his expertise extends to the intricate realm of downstream processing, where he has mastered the art of isolating and purifying these complex therapeutic proteins. His proficiency ensures that the proteins he has developed not only demonstrate high efficacy but also adhere to the stringent standards required for safe and dependable clinical application.

During his tenure at Shafigluco Chem, Mr. Islam has made pioneering contributions in the production and refinement of essential components, such as soluble rice protein and maltodextrin. With meticulous attention to detail and an unwavering commitment to quality, he has played a vital role in crafting these ingredients, which serve as fundamental building blocks for a diverse range of food products.

Throughout his time at AB Mauri Fermentation Pakistan, he has immersed himself in the intricate world of food technology, with a specific focus on fermentation processes. His role has empowered him to harness the power of microorganisms to transform raw materials into a wide array of flavorful and nutritious products. Through thorough research and experimentation, he has developed a comprehensive understanding of fermentation techniques that optimize taste, texture, and nutritional value.

Selected Publications:

1. Ashraf, F., Khan, M. A., Ahmed, N., Umar, M., Khan, M. I., Akram, M., … & Malik, K. (2023). Development of transgenic algae strain expressing CTB-M2e fusion gene an approach towards the development of a universal edible vaccine in Algae. Journal of Biotechnology. Impact Factor = 4.1
2. Hamid Bashir, Nadeem Ahmed, Ahmad Usman Zafar, Mohsin Ahmad Khan, SaadTahir,Muhammad Islam Khan, Faidad Khan, Tayyab Husnain: Simple procedure applying lactose induction and one-step purification for high-yield production of rhCIFN. Biotechnology and Applied Biochemistry 08/2015; 63(5). DOI:10.1002/bab.1426
3. Nadeem Ahmed, Hamid Bashir, Ahmad Usman Zafar, Mohsin Ahmad Khan, Saad Tahir, Faidad Khan, Muhammad Islam Khan, Muhammad Akram, Tayyab Husnain: Conditions optimization for high level expression and purification of human recombinant consensus interferon (rh cIFN) and its characterization. Biotechnology and Applied Biochemistry 11/2014; 62(5). DOI:10.1002/bab.1320
4. Nadeem Ahmed, Ahmad Usman Zafar, Mohsin Ahmad Khan, Saad Tahir, Muhammad Islam Khan, Hamid Bashir, Faidad Khan, Samreen Sarwar, Sadaf Ilyass, Tayyab Husnain: Matrix-assisted refolding and purification of placenta-derived recombinant human interleukin-6 produced in Escherichia coli. Biotechnology and Applied Biochemistry 09/2014; 61(5). DOI:10.1002/bab.1205
5. Mohsin Ahmad Khan, Faidad Khan, Nadeem Ahmad, Muhammad Islam Khan, Ahmad Usman Zafar, Tayyab Husnain: Expression line approach to recombinant human epidermal growth factor into the yeast, Pichia pastoris from Huh-7 cell line. Molecular Biology Reports 01/2014; 41(3). DOI:10.1007/s11033-013-2989-1
6. Mohsin Ahmad Khan, Nadia Hassan, Nadeem Ahmad, Muhammad Islam Khan, Ahmad Usman Zafar, Faidad Khan, Tayyab Husnain: Studies to analyze the relation between IFNα2b gene dosage and its expression using Pichia pastoris based expression system. Yeast 01/2014; 31(1). DOI:10.1002/yea.2990